NATURE OUTLOOK The global effort to eliminate the disease depends heavily on blocking the most common mode of viral infection

NATURE OUTLOOK If biological ageing can be slowed, halted or rewound, are the machine-learning algorithms the best way to measure it? Some experts are unconvinced.

NATURE OUTLOOK Several major organizations are calling for radical reforms to improve oral health. What’s holding them up?

NATURE OUTLOOK The ability to develop animals that have human organs could save the lives of people waiting for transplants, but ethical issues still need to be faced.

NATURE OUTLOOK Trials to replace the pancreatic β cells that are destroyed by this autoimmune disease are raising hopes of a cure. By Liam Drew

THE INDEPENDENT When Catherine Impey started a radical newspaper that challenged Victorian readers to think about race, her ideas were far ahead of her time. Liam Drew takes a closer look

Unpublished Coda to article in THE INDEPENDENT Impey never again operated at the level of national or international politics or journalism. But she forever stood up for the causes she believed in

FUTURA How to map 37 trillion cells. Founded and led by two pioneering female scientists, the Human Cell Atlass marries technical innovation with open science and collaborative spirit..

NATURE OUTLOOK To strike a ball moving at lightning speeds in baseball, tennis and cricket, athletes and coaches are increasingly embracing training techniques involving virtual reality.

SIMONS FOUNDATION The most comprehensive wiring map to date of the fruit fly brain has transformed the field of neuroscience, identifying new cell types and reconfiguring circuit models. Are neuroscientists now ready to tackle the mouse brain?

FUTURA

If a microscopic film crew could make a movie of the cellular landscape of your brain, aside from the blood coursing through the brain’s 650 km of blood vessels, most cells would be largely motionless except microglia. They would be the hyperkinetic dancing stars of this production.

NATURE OUTLOOK Migraines are often associated with colourful visual disturbances called auras, but many mysteries remain about how they fit into the wider biology of the syndrome.

NATURE OUTLOOK Molecular pathways of inflammation, the cystic fibrosis microbiome and other highlights from clinical trials and laboratory studies.

SIMONS FOUNDATION Computer vision and machine learning technologies are creating ever more precise records of animal behavior. Now, neuroscientists must figure out how best to use these techniques to understand neural activity.

Cancer Research UK PARP inhibitors are rapidly transforming the treatment of ovarian, breast, prostate and other types of cancer. To develop these drugs, researchers supported by Cancer Research UK had to decipher how blocking DNA repair could expose a weak point in the biology of cancer cells.

QUANTA The nervous systems of foraging and predatory animals may prompt them to move along a special kind of random path called a Lévy walk to find food efficiently when no clues are available.

NATURE MEDICINE Neural implants can give people with neurological disorders a new lease on life. But it can all be taken all away at the end of the trial.

NATURE OUTLOOK Researchers strive to understand how microbes affect health and disease. Liam Drew picks the highlights of 2019.

NATURE OUTLOOK When immunization rates dip, legislation is often strengthened. But does the evidence stack up?

SIMONS FOUNDATION Seemingly meaningless movements — even a quick twitch of a limb — produce abundant, widespread and high-dimensional activity in the cortex. How might the brain use this information?